4/6/09

Just going out for a jog!‏

"I race in order to dig deep within myself and see what I'm really made of." MAGGIE, Runner from Idaho


Typical Monday night group run where there were many of the usual runners. This was the first monday group run for the month, so there usually is a lot more people and the NCAA finals are tonight.


CD and I went out along the piers and there was a new guy who followed us to the second piers, he wanted to hang with us, but we told him that the other group was better suited and we slowed down a little, but then sped off for our own workout.


We did the usual route and came back up and did the piers. As everyone went to the bar, we went back to my office to change.


As I was leaving my office, one of the partners from my firm saw me and CD. She asked if I was going for a JOG.

CD took great offense to this after the fact that his wife, EBD hates when people say going out for a jog or associates runners with Joggers.


This leaves the question of what is the difference between joggers and runners.

Is Alzheimer's caused by overworking the brain in your youth?
By Fiona Macrae
Last updated at 12:52 AM on 07th April 2009

Some of us may develop Alzheimer's disease in old age because our brains worked too hard when we were younger, scientists say.

A study has found that in young men and women genetically predisposed to the degenerative disease, the brain's memory hub is hyperactive.

The research raises the possibility that some develop Alzheimer's because their memory is simply worn out.

It could also pave the way for a test capable of spotting future dementia patients while they are young and healthy. Those at high risk could be offered early treatment or given lifestyle advice to help them.

The researchers, from Oxford University and Imperial College London, compared the brain activity of young people with a common gene that can greatly increase the odds of Alzheimer's, to those without it.

The volunteers, who were as young as 20, did equally well on tasks which tested their mental skills.

But scans revealed the brains of those with the APOE4 gene worked harder when set a memory task - and when at 'rest', according to the journal Proceedings of the National Academy of Sciences.

Dr Christian Beckmann, of Imperial College, said: 'Our brains are always active - our minds wander even when we're not carrying out specific tasks.


'We were surprised to see that even when the volunteers carrying APOE4 weren't being asked to do anything, you could see the memory part of the brain working harder than it was in the other volunteers. Not all APOE4 carriers go on to develop Alzheimer's, but it would make sense if in some people, the memory part of the brain effectively becomes exhausted from overwork, and this contributes to the disease.

'This theory is supported by studies that have found the opposite pattern in people who have developed Alzheimer's, with these people showing less activity than normal in the memory part of the brain.'

Dr Clare Mackay, from Oxford University, said: ' These are exciting first steps towards a tantalising prospect: a simple test that will be able to distinguish who will go on to develop Alzheimer's.'

Rebecca Wood, of the Alzheimer's Research Trust, said: 'This significant development takes us a step closer to accurately predicting who will develop Alzheimer's before any symptoms become apparent.

'However, we are not yet at that stage. Those with the APOE4 genetic variant, while at a statistically higher risk of developing the disease, will still not develop Alzheimer's in most cases.
'The causes of Alzheimer's are complex - both genetic and environmental. And if we can understand these better, we can enhance efforts to help people lower their risks.


'We can reduce our risk of developing dementia by maintaining a balanced diet, exercising regularly and keeping our brains active, particularly through social activities.'

Alzheimer's and other dementias affect 700,000 in the UK, costing £17billion annually.

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